Role of sulfonamide moiety in non-prostanoid txa2 receptor antagonist kt2-962 : modifications of this moiety and the resulting activities
1993
Abstract Modification of sulfonamide moiety in non-prostanoid thromboxane A 2 (TXA 2 ) receptor antagonist, KT2-962 with double amide, sulfonamide-amide, (thio)semicarbazone, inverse sulfonamide and N-sulfonylcarboxamide is described. Unlike prostanoid TXA 2 antagonists, the importance of sulfonamide moiety for the activity of non-prostanoid TXA 2 receptor antagonist, KT2-962 was confirmed.
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