Conditional Reprogramming Inducing Clinical Cells Proliferation: New Research Tools in Tumor and Inflammatory-related Diseases.

The relationships between inflammation and tumor are very complex: inflammation maybe induce cancer, on the other hand, cancer cells would release inflammatory cytokines into microenvironment around them. So it is hard to identify cancer and inflammation, especially early tumor and chronic inflammation in clinical patients screening. Conditional reprogrammed cells (CRCs) allow establishing a stable cell cultures of normal and tumor epithelial cells from patients' tissues. This new technique of living tissue culture can retain the genotype and phenotype of tumor cells and normal cells, and realize cell growth. It can provide reliable cell culture detection to screen early cancer from chronic inflammation and even constructing models in vivo for cancer chemotherapy-resistant patients.