Interaction of manganese(II) with the hybrid molecule (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline: Structure and biological profile

Abstract The interaction of the recently reported quinazoline derivative (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline (L) with MnCl2·4H2O resulted in the formation of two manganese(ΙΙ) complexes which were characterized by single-crystal X-ray crystallography, namely [Mn(L)(Cl)2]·H2O, 1·H2O, and [Mn(L)(Cl)(HCOO)(H2O)]·H2O, 2·H2O. The biological profile of complex 2 was further assessed in regard to the binding affinity with calf-thymus DNA, the cleavage ability of pBluescript II KS plasmid DNA, the interaction with bovine serum albumin and the ability to scavenge 1,1-diphenyl-picrylhydrazyl and 2,2΄-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals and to reduce H2O2.