Oxidative Damage and Genotoxicity of Organic Chemical Pollutants from the Source Water and Running Water in Baotou to Mice

Objective To explore the oxidative damage and genotoxicity of organic chemical pollutants from running water and the source water in Baotou reach of the Yellow River to mice. Methods The Kunming mice were treated with the organic extract solutions of the Yellow River water and running water by gavage at different concentration,once a day and the activity of the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the content of malondialdehyde (MDA) in the liver and kidney and the rate of micronucleus were determined. Results SOD and GSH-Px activity in the liver and kidney in the groups treated with the water of three sections of Yellow River in Baotou City decreased as the exposure dose increased. Except the low concentration group of running water,the MDA content in the liver and kidney and the micronucleus rate increased significantly compared with the control (P0.05), the MDA content and micronucleus rate in the groups treated with the water of middle section of the Yellow River in Baotou City was the highest. Conclusion The organic extracts from running water and the water of the Baotou reach of the Yellow River can cause oxidative damage and mutagenesis in the mice,the middle section of water source showed serious oxidative damage and genotoxicity.