An efficient protocol for the synthesis of monofluoroalkylated (hetero)arenes via Pd-catalyzed α-(hetero)arylation of α-fluoroketones with (hetero)aryl bromides
2020
Abstract An efficient synthesis of monofluoroalkylated N-heteroarenes using α-fluoroketones as monofluoroalkyl reagents was developed. A variety of novel α-(hetero)aryl-α-fluoroketones and monofluoroalkylated N-heteroarenes were obtained in moderate to good yields. Notable advantages of this protocol include a low catalyst loading, easily prepared monofluoroalkyl reagents and wide substrate scope.
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