Asymmetric Biginelli Reaction of by Primary Amine Thiourea Catalysts

A novel spriooxindole was synthesized by asymmetric Biginelli reaction of isatin,urea and ethyl acetoacetate using primary amine thiourea as the catalyst,D-camphorsulfonic acid as the additive and DMF as the solvent.The structure was characterized by 1H NMR,13C NMR and HPLC.