REPORT on the First International Workshop on Chromosome 9 held at Girton College Cambridge, UK, 22–24 March, 1992

Ann. Hum. Genet. (1992), 56, 167-221 Printd in &eat Britain REPORT on the First International Workshop on Chromosome 9 held at Girton College Cambridge, UK, 22-24 March, 1992 Prepared by: S. POVEY, M. SMITH, J. HAINES, D. KWIATKOWSKI, J . FOUNTAIN, A. BALE, C. ABBOTT, I. JACKSON, M. LAWRIE and M. HULTEN The meeting was attended by 70 participants whose names and addresses are included in an appendix t o this report. Fifty-four abstracts were received and the data presented on posters. The main role of the meeting was seen as the construction of a consensus map of chromosome 9, together with a sharing of knowledge about resources such as hybrids, libraries and new polymorphisms. The group divided into separate working parties t o consider 9p, 9cen-9q32, 9q33-9qter, global problems and comparative mapping. The findings of each of these groups are included in this report. There was a separate discussion of resources which is also summarized. Two databases were discussed and demonstrated (GDB by Bonnie Maidak and ldb by Andy Collins). The chromosome 9 workshop was preceded on the afternoon of Sunday, 22 March by a workshop on Tuberous Sclerosis. Because of the relevance of this to chromosome 9q34 a report on this workshop is included in that section. A further subgroup met on 24 March t o discuss the CEPH chromosome 9 consortium map and a brief report on their progress was produced. In accordance with the recommendation of the Global group an attempt has been made to reference information in the maps but it is recognized that this is incomplete. Within the text of this report a name without a date refers to an abstract a t this meeting (see end of report). A name with a date refers t o a publication listed in the references and these are generally confined to very recent or in press references. A verbal communication at the meeting is identified as a personal communication. For authoritative referencing of published information the reader should consult GDB. It is also planned t o enter information into ldb so that in future it may be possible to compare a map produced by artificial intelligence with that produced by a human consensus view ! It was decided to hold a further workshop on chromosome 9 in April or May 1993 and David Kwiatkowski kindly agreed to organize this in Boston. CHROMOSOME 9p A number of groups co-ordinated by Jane Fountain combined to produce a n ordered map of 9p (Figs 1, 2 ) . This incorporates a partial map of 9p supported by multipoint linkage analysis, pulsed field gels and FISH (Fountain et al. and Fountain et al. 1992). Most of the detailed information on 9p comes from intensive effort by several workers to investigate the position of a potential tumour suppressor gene or genes in gliomas, leukaemias, non-small cell lung carcinomas (NSCLCs) and melanomas. Deletion mapping combined with isolation of the region on a 900 kb YAC contig has led to the determination of the physical position of 27 human interferon genes (Ilia2 et al., Olopade et al.). The position of WP4 remains uncertain. From the minimal region of overlap of an extensive series of deletions in leukaemias and gliomas Olopade et al. suggested the existence of a tumour suppressor gene between the proximal end of IFNA and the gene MTAP. Other groups also reported results consistent with this (Nobori et al., Middleton et al., Heyman et al.). I2 H G E 56