Diffusion-weighted magnetic resonance imaging of the brain of neurologically normal dogs

OBJECTIVE To acquire MRI diffusion data (apparent diffusion coefficient [ADC] and fractional anisotropy [FA] values, including separate measures for gray and white matter) at 3.0 T for multiple locations of the brain of neurologically normal dogs. ANIMALS: 13 neurologically normal dogs recruited from a group of patients undergoing tibial plateau leveling osteotomy. PROCEDURES: MRI duration ranged from 20 to 30 minutes, including obtaining preliminary images to exclude pathological changes (T2-weighted fluid-attenuated inversion recovery transverse and dorsal images) and diffusion-weighted images., RESULTS: Globally, there were significant differences between mean values for gray and white matter in the cerebral lobes and cerebellum for ADC (range of means for gray matter, 0.8349 × 10−3 s/mm2 to 0.9273 × 10−3 s/mm2; range of means for white matter, 0.6897 × 10−3 s/mm2 to 0.7332 × 10−3 s/mm2) and FA (range of means for gray matter, 0.1978 to 0.2364; range of means for white matter, 0.5136 to 0.6144). These ...