GSK973 Is an Inhibitor of the Second Bromodomains(BD2s) of the Bromodomain and Extra-Terminal (BET) Family

Alex G.S. Preston,Stephen John Atkinson,Paul Bamborough,Chun-wa Chung,Laurie J. Gordon,Paola Grandi,James Gray,Lee Andrew Harrison,Antonia J Lewis,Dave Lugo,Cassie Messenger,Anne-Marie Michon,Darren Jason Mitchell,Rab K. Prinjha,Inmaculada Rioja,Jon T. Seal,Simon Taylor,Pierre Thesmar,Ian David Wall,Robert J. Watson,James Michael Woolven,Emmanuel Hubert Demont

GSK973 Is an Inhibitor of the Second Bromodomains(BD2s) of the Bromodomain and Extra-Terminal (BET) Family

2020

Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events have been reported. These inhibitors in...

Keywords:

Bromodomain
Biology
In vivo
Adverse effect
safety profile
Pharmacology

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