Hyperoxic Intubation Apnoea: An In Vivo Model for the Proof of the Christiansen-Douglas-Haldane Effect

The Christiansen-Douglas-Haldane effect (HALDANE effect) describes the different CO2 binding capacity of haemoglobin on its degree of oxygenation and was first demonstrated in vitro in 1914 (Christiansen, Douglas and Haldane, 1914).