Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China.

Levels of serum and urinary sphinganine (Sa) and sphingosine (So), the Sa/So ratio, and urinary-free fumonisin B1 (FB1) were determined in a cross-sectional study consisting of 43 adults in Huaian and 34 adults in Fusui, China. Home-produced corn had 100% contamination with FB1. There were 93.0% (40/43) of Huaian subjects and 52.9% (18/34) of Fusui subjects with daily FB1 intakes greater than 2 µg kg−1 body weight, which showed a significant difference (p < 0.01). Levels of sphinganine and sphingosine and the Sa/So ratio were not correlated with levels of dietary exposure. The median level of the serum Sa/So ratio in Huaian subjects (0.41, range = 0.14–0.85) was significantly lower than that in Fusui subjects (0.78, range = 0.57–1.08) (p < 0.01). The median level of the urinary Sa/So ratio was also significantly lower in Huaian subjects (0.31, range = 0.08–1.33) than in Fusui subjects (0.57, range = 0.03–2.52) (p < 0.01). Urinary-free FB1 was detected in 83.7% (36/43) of Huaian samples and in 82.4% (28/34...