Metabolism of bromobenzene : Analytical chemical and structural problems associated with studies of the metabolism of a model aromatic compound

Abstract Our studies of bromobenzene metabolism have shown that the 3,4-oxide is metabolized to 3- and 4-bromophenol through an extended glutathione pathway. The mechanism of sulfur elimination from a dihydrobromobenzene metabolite is not known, although it is known that the aromatization reaction will occur in a 9000- g supernatant fraction of rat liver. The hepatotoxic and nephrotoxic metabolites of bromobenzene are most likely bromothiocatechols and a bromothiopyrogallol, respectively.