Scalable Synthesis of the Potent HIV Inhibitor BMS‐986001 by Non‐enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT).

Adrian Ortiz,Tamas Benkovics,Gregory L. Beutner,Zhongping Shi,Michael Bultman,Jeffrey Nye,Chris Sfouggatakis,David R. Kronenthal

Scalable Synthesis of the Potent HIV Inhibitor BMS‐986001 by Non‐enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT).

2015

Adrian Ortiz
Tamas Benkovics
Gregory L. Beutner
Zhongping Shi
Michael Bultman
Jeffrey Nye
Chris Sfouggatakis
David R. Kronenthal

Title compound (IX*) is prepared from racemic lactol (I) using small-molecule-mediated dynamic kinetic resolution and a selective pyranose-to-furanose ring contraction as the key steps.

Keywords:

Lactol
Combinatorial chemistry
Kinetic resolution
Enzyme
Kinetic energy
Organic chemistry
Chemistry
anti hiv activity
non enzymatic
human immunodeficiency virus

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