Synthesis and characterization of potential tumor scintigraphic agents.
1987
Abstract Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with 99m Tc. Three new organometallic compounds, with iminodiacetic acid as the 99m Tc chelating group and 2,3-diaminopropionamide as the platinum complexing group, have been prepared and characterized. Preliminary biodistribution studies in tumor bearing mice support the utility of this approach.
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