Enzymatic Synthesis of Optical Pure β-Nitroalcohols by Combining D-Aminoacylase-Catalyzed Nitroaldol Reaction and Immobilized Lipase PS-Catalyzed Kinetic Resolution.

An enzymatic method which combines D-aminoacylase catalyzed nitroaldol reaction and lipase PS-IM catalyzed acyl resolution reaction was constructed to obtain optically pure β-nitroalcohols in organic media under mild conditions. A series of β-nitroalcohols were synthesized and then resolved, with excellent ee values (>95%) and yields mostly, giving enantiomerically pure acetate and alcohol of the opposite configuration simultaneously.