P38 inhibitors and methods of use.

Compound it comprising solvates and pharmaceutically acceptable salts thereof, which is selected from: 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; [5- (4-fluorophenoxy) -1-isobutyl-1H-indazol-6-yl] -morpholin-4-yl-methanone; [5- (4-fluorophenoxy) -1-isobutyl-1H-indazol-6-yl] - (4-methylpiperazin-1-yl) -methanone; (1-benzylpiperidine-4-yl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (2-benzylaminoethyl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (2-piperidin-yl-ethyl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (2-pyrrolidin-1-yl-ethyl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (3-morpholin-4-yl-propyl) -amide 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (3-dimethylaminopropyl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (2-dimethylaminoethyl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; methyl- (1-methylpiperidin-4-yl) 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; [3- (methylphenylamino) -propyl] amide 5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; tert-butyl ester of 3 - {[5- (4-fluorophenoxy) -1-isobutyl-1H-indazol-6-carbonyl] -amino} -pyrrolidine-1-carboxylic acid; (2-dimethylaminoethyl) 5- (4-fluorophenoxy) -1- (2,2,2-trifluoroethyl) -1H-indazole-6-carboxylic acid; (2-dimethylaminoethyl) 5- (4-fluorophenoxy) -1-methyl-1H-indazole-6-carboxylic acid; (2-dimethylaminoethyl) 5- (4-fluorophenoxy) -1H-indazole-6-carboxylic acid; methyl ester 4-amino-2 - {[5- (4-fluorophenoxy) -1-isobutyl-1H-indazol-6-carbonyl] -amino} -butyric acid; methyl ester 4-amino-2 - {[5- (4-fluorophenoxy) -1- (2,2,2-trifluoroethyl) -1H-indazole-6-carbonyl] -amino} -butyric acid; methyl ester 4-amino-2 - {[5- (4-fluorophenoxy) -1-methyl-1H-indazol-6-carbonyl] -amino} -butyric acid; (S) -N- (4-amino-1-hydroxybutan-2-yl) -5- (4-fluorophenoxy) -1-isobutyl-1H-indazole-6-carboxamide; (S) -methyl 2- (5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxamide) -4- (dimethylamino) butanoate; (S) -5- (2,4-difluorophenoxy) -N- (4- (dimethylamino) -1-hydroxybutan-2-yl) -1-isobutyl-1H-indazole-6-carboxamide; (1-hydroxymethyl-3-isopropylaminopropyl) amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (S) -2 acid - {[5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazol-6-carbonyl] -amino} -4-dimethylaminobutyric; (1-hydroxymethyl-3-piperidin-1-ylpropyl) amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (3-dimethylamino-1-dimetilcarbamoilpropil) amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (3-dimethylamino-1-metilcarbamoilpropil) amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (1-carbamoyl-3-dimethylaminopropyl) amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; [1- (2-dimethylaminoethyl) -2-hydroxy-2-methylpropyl] amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl acid 1H-indazole-6-carboxylic acid; {1-hydroxymethyl-3 - [(2-methoxyethyl) methylamino] propyl} amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; [3-dimethylamino-1- (2-hydroxyethylcarbamoyl) propyl] amide (S) -5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazole-6-carboxylic acid; (3-dimethylaminopropyl) amide 5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazol-6-sulfonic acid; (S) -methyl 2- (5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazol-6-sulfonamide) -4- (dimethylamino) butanoate; [2- (1-methylpyrrolidin-2-yl) -ethyl] 5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazol-6-sulfonic acid; and (2-dimethylaminoethyl) 5- (2,4-difluorophenoxy) -1-isobutyl-1H-indazol-6-sulfonic acid.