Ca 2+ -Permeable Canonical TRP Channels in Mouse m. LAL Muscle Fibers

It has been shown by fluorescence microscopy that membranes of mouse skeletal muscle fibers contain canonical TRP channels (TRPCs) of four subfamilies, including seven known classified subtypes. In the area of the neuromuscular junction the most represented are TRPC5 channels and the least are TRPC2 channels. Some subtypes of TRPC channels (1, 3, 4, and 5) are closely associated with the membranes of the sarcoplasmic reticulum of muscle fibers, with TRPC5 channels being the most represented in these structures. There is no local concentration of TRPC channels of all subtypes (1–7) exclusively in the area of neuromuscular junction, which does not support the hypothesis of a possible neurotrophic control over the distribution of channels of this family in the muscle fiber.