Synthesis and quality control of 99mTc-p-butyl IDA

Abstract A procedure is described for synthesis of p -butyl IDA and for identification of the product by i.r. and NMR spectroscopy and by chemical analysis. A method for preparing this compound by “instant” technique and for its labelling with 99 m Tc is also given, as well as a procedure for control of the chemical and biological properties of the radiopharmaceutical. Radiochemical study shows a high labelling yield of 95%. Investigation of the biodistribution proves that this preparation is a good hepatobiliary reagent, suitable for use in investigation of the liver functions and for quantitative visualization of the hepatobiliary system.