Synthesis and Structure—Activity Relationships of Aminoalkylazetidines as ORL1 Receptor Ligands.

Wen-Lian Wu,Mary Ann Caplen,Martin S. Domalski,Hongtao Zhang,Ahmad Fawzi,Duane A. Burnett

Synthesis and Structure—Activity Relationships of Aminoalkylazetidines as ORL1 Receptor Ligands.

2003

Wen-Lian Wu
Mary Ann Caplen
Martin S. Domalski
Hongtao Zhang
Ahmad Fawzi
Duane A. Burnett

A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified.

Keywords:

ORL1 receptor
Stereochemistry
Structure–activity relationship
Ligand
Chemistry
Organic chemistry

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