Pyrrolopyridazines as potassium channel inhibitors ions

A compound of formula (I) ** ** Formula or an enantiomer, a diastereomer, a tautomer, a salt or solvate thereof, wherein: A is - (CH2) m-R2, -CH (R26) - R2, - (CH2) n-1-O-R2, - (CH2) n-1-NR25-R2, -CH (R26) -CO 2 R 2 or - (CH2) n-1-NR25-CO2-R2; R1 is C1-10 alkyl substituted with 1-2 -OH, C1-10 haloalkyl, C2-12 alkenyl or C3-10 cycloalkyl, wherein the cycloalkyl may be substituted with 0-2 R13, or Formula ** ** either which may be substituted with 0-2 R13; R2 is phenyl, cyclopentyl, cyclohexyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, piperidinyl, pyridinone, pyrrolidinyl, tetrahydropyranyl or thiazolyl, any of which is substituted with 0-2 R2a; R2a, at each occurrence, is independently H, -OH, F, Cl, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl , C6-10 aryl, a heteroaryl 4- to 12-membered heterocyclyl with 4 to 12 members, a C1-10 alkyl-heteroaryl 4 to 12 members, -CN, -NO2, - (CH2) m-SO2R14, -NR14SO2R14,> = O, -CONR14R14, - (CH2) m-SO2NR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, - SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C (> = NOR14) NR14R14, -CONR14OR14 or -NCOR14, wherein alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be substituted with 0 -2 R14a, and the heteroaryl and heterocyclyl consisting of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R3 is phenyl, pyridinyl, pyrimidinyl or dihydropyran or tetrahydropyran, any of which may be substituted with 0-1 R3a; R3a is halo, CN, NH2, -O-C1-3alkyl or morpholinyl; ** ** Formula R13, in each instance, is independently H, -OH, F, Cl, Br, I, CN, C1-10alkyl , C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C2-12 alkynyl, C6-10 aryl, a heteroaryl 4- to 12-membered heterocyclyl 4 to 12 members, a C1 -10-heteroaryl 4 to 12 members, -CN, -NO2, - (CH2) m-SO2R14, -NR14SO2R14,> = O, -CONR14R14, - (CH2) m-SO2NR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, -SO2NR14CONR14R14, -NR14CO2R14, -CO2R14, -NR14R14, -NR14CONR14R14, -C (> = NOR14) NR14R14, -CONR14OR14, -NCOR14 or OR14, wherein alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be substituted with 0-2 R14a, and the heteroaryl and heterocyclyl consisting of carbon atoms and 1, 2, 3 or 4 heteroatoms selected independently selected from the group consisting of N, S or O; R14, at each occurrence, is independently selected from hydrogen, C1-10, C3-10, C6-10 aryl, a heteroaryl 4 to 12 membered ring or a 4- to 12 members, wherein the alkyl, cycloalkyl alkyl, aryl, heteroaryl and heterocyclyl may be substituted with 0-3 R14a and the heteroaryl and heterocyclyl consisting of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O, or alternatively, two R14 are taken together with the atoms to which they are attached to form a cyclic ring, wherein the cyclic ring may be substituted with 0-1 R14a, and optionally containing 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of in N, S or O; R14a, in each case, a heterocyclyl 4 is independently selected from F, Cl, Br, I, C1-10 alkyl, C1-10 haloalkyl, C6-10 aryl, C3-10 heteroaryl 4 to 12 members to 12 members, F, Cl, Br, I, -CN, -NO2, -CO2R26, -CO2NR24R24, -OCF3, -OR25,> = O, -CONR24R24, -COR 24, -SO2R24, -NR24R24, -NR24CO2R24, - SO2NR24R24 or C6-10 aryl-C1-10 alkyl, wherein the heteroaryl and heterocyclyl consisting of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O; R24, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-6 cycloalkyl or phenyl; R25, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-6 cycloalkyl or phenyl; R26, at each occurrence, is independently selected from hydrogen, C1-10 alkyl, C3-6 cycloalkyl or phenyl; m is 0 to 4; n is 0 to 4; and n-1 is from 2 to 4.