Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats

Following the publication of the above article, an interested reader drew to our attention that, in Fig. 4A, in which the authors had presented a western blot image depicting protein expression of IL18, IL1beta, NLRP3 and betaactin from synovial tissue lysates from osteoarthritic rats, upon close examination of the figure a striking similarity was noted between the bands shown for the IL18 and NLRP3stained Sham group experiments, although the bands appeared in an inverted position relative to each other. Following an enquiry with the authors, they realized that they had included incorrect data for this figure; an amended version of Fig. 4, showing the correct data for NLRP3, is shown opposite. Secondly, the authors have realized that, at various points throughout the paper, two miRNAs were written incorrectly: Specifically, references to an 'miR352' should have appeared as miR532, and 'miR233' should have been written as miR223. This error affected the presentation of Fig. 2; therefore, a revised version of this figure, with the miRNAs correctly labelled as miR532 and miR223 respectively, is also shown opposite. Furthermore, mi233 should have been written as miR223 at the following places in the text: p. 4051, righthand column (RHC), line 10 ("Furthermore, the miR223regulated...); p. 4054, Results section, lefthand column (LHC), third subheading ("miR223 negatively regulates the expression of NLRP3."); and in the concluding paragraph of the Discussion on p. 4056, LHC, miR233 should have been written as miR223 in all five instances where this occurred (lines 4, 7, 8, 9, and 10 of this paragraph). Finally, the second sentence featured in the subsection of the Results section entitled "Expression validation of miRs by RTqPCR" on p. 4054 contained additional errors. This sentence should have appeared as follows (changed text is highlighted in bold): "The expression of miR223, 100, 345, 130, 382, 9a and 183 were upregulated, whereas miR377, 532, 200b were downregulated with a fold change of >/=1.5, similar to the microarray data (Fig. 2). All the authors agree to the contents of this Corrigendum, and apologize to the Editor of Molecular Medicine Reports and to the readership for any inconvenience caused. [the original article was published in Molecular Medicine Reports 18: 40514057, 2018; DOI: 10.3892/mmr.2018.9385].