Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects
2016
Rationale
Benzodiazepines are effective anxiolytics, hypnotics, and anticonvulsants but unwanted side effects, including abuse potential, limit their use. A possible strategy to increase the therapeutic index of this drug class is to combine benzodiazepines with neuroactive steroids.
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