Atrial natriuretic peptide inhibits epithelial-mesenchymal transition (EMT) of bronchial epithelial cells through cGMP/PKG signaling by targeting Smad3 in a murine model of allergic asthma

Shuyuan Chu,Xiufeng Zhang,Yabing Sun,Yaxi Liang,Jingyi Sun,Minyan Lu,Jianwei Huang,Ming Jiang,Libing Ma

Atrial natriuretic peptide inhibits epithelial-mesenchymal transition (EMT) of bronchial epithelial cells through cGMP/PKG signaling by targeting Smad3 in a murine model of allergic asthma

2019

Shuyuan Chu
Xiufeng Zhang
Yabing Sun
Yaxi Liang
Jingyi Sun
Minyan Lu
Jianwei Huang
Ming Jiang
Libing Ma

AbstractBackground: Atrial natriuretic peptide (ANP) inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in human airway cells. We aim to explore the role and mechanism of ANP on EMT of...

Keywords:

Asthma
Biochemistry
Epithelial–mesenchymal transition
Cancer research
Atrial natriuretic peptide
Biology
murine model
allergic asthma
human airway

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