Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

Eva-Maria Strauch,Steffen M. Bernard,David La,Alan J Bohn,Peter Lee,Caitlin E. Anderson,Travis Nieusma,Carly A. Holstein,Natalie K. Garcia,Kathryn A. Hooper,Rashmi Ravichandran,Jorgen Nelson,William Sheffler,Jesse D. Bloom,Kelly K. Lee,Andrew B. Ward,Paul Yager,Deborah H. Fuller,Ian A. Wilson,David Baker

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

2017

A method to target trimeric membrane proteins by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin.

Keywords:

Molecular engineering
Molecular biology
Plasma protein binding
Glycoprotein
Membrane protein
A-site
Hemagglutinin (influenza)
Biology
Protein design
Binding protein

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