Explore the mechanism of action of cinnamaldehyde against Providencia rettgeri: Induced alteration in choline metabolism in C57BL/6J mice

Atherosclerotic cardiovascular disease (ACD) is the leading cause of mortality worldwide. The present research was designed to assess the antimicrobial activity of Cinnamaldehyde using Providencia rettgeri and anti-atherosclerotic potential of cinnamaldehyde in choline - fed C57BL/6J mice. Molecular Docking was done to assess the protein binding ability of cinnamaldehyde with FMO3 enzyme. From molecular docking it was concluded that cinnamaldehyde inhibited the FMO3 enzyme which catalyses the conversion of TMA to TMAO, thus reduced the risk of atherosclerosis. Antimicrobial effects of cinnamaldehyde, cinnamon oil and ciprofloxacin were demonstrated by turbidimetric method. Inhibition of bacteria by test drug i.e. cinnamaldehyde and standard drug i.e. ciprofloxacin was found to be significant (p