Copper-catalyzed [1,3]-alkoxy rearrangement for the selective synthesis of polycyclic ortho-aminoarenol derivatives
2021
Copper-catalyzed [1,3]-alkoxy rearrangement reactions of polycyclic arenes, such as naphthalenes and phenanthrenes, proceeded efficiently to afford the corresponding ortho-aminoarenol derivatives in good to excellent yields. Through the appropriate choice of N-heterocyclic carbene (NHC) ligand, the reactions are applicable to not only a methoxy group but also readily deprotectable p-nitrobenzyl group. In addition, rearrangement of the N-methoxyamino group on the benzene ring of indoles proceeded efficiently, affording the corresponding functionalized indoles in a site-selective manner.
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