Reply to Liu: Amino acid 104 asparagine/glutamic acid of p53 is an adaptively selected site for extreme environments in mammals of the Tibet plateau.

In our paper, we substantiate the fact that codon 104 variation is adaptive in highland Tibet plateau mammals (1). Liu’s letter (2) claims that codon 104 is not adaptive, which is only based on searching the sequence prediction in National Center for Biotechnology Information (NCBI) without experimental evidence.