Formulation and evalution of Levofloxacin hemihydrate immediate release tablets

The presentation deals with formulation of immediate release tablet of levofloxacin using super disintegrant such as Croscarmelose sodium and crospovidone. To enhance the rapid absorption rate to treat the case of bacterial infection. The study had been carried out by formulating 8 formulations by varying the concentration of disintegrating agent. The optimized batch F8 showed a disintegration time of about 55sec and released 99.08% of drug at the end of 30min in 0.1N HCL. The optimized batch F8 had been studied for the release in various dissolution mediums were it found to be about 90% in medium such as purified water, 0.1(N) HCl, Phosphate Buffer and acetate Buffer. Hence the formulated batch had the tendency to release the drug as rapid as possible irrespective of the medium. The stability studies had been carried out for a period of 1month in both accelerated and intermediate condition was no significant change had been observed.