Evaluation of oral formulation of Saussurea lappa seed extract for antihyperlipidemic activity in experimental rats- a pilot study.

Objective: The aim of this study has been to investigate the possible antihyperlipidemic effect of oral formulation of Saussurea lappa seed extract in triton-x-100 (100mg/kg b.w.)-induced hyperlipidemic rats. Materials and Methods: The oral formulation of hydro alcoholic extract of Saussurea lappa seed were evaluated for antihyperlipidemic activity in triton-x-100 induced hyperlipidemic rats. The formulation was made in the form of suspension taking a natural suspending agent acacia gum (5%). Through blood collection various parameters like-total cholesterol, triglycerides, LDL and VLDL were determined. The results of the study were expressed as mean± S.E.M and data was analyzed by using two way analysis of variance test (ANOVA) followed by post test Bonferroni. Values with P < 0.05 were considered as significant. Results: Oral administration of 200 mg/kg body wt. of the herbal formulation of Saussurea lappa seed exhibited a significant reduction (P<0.01) in serum lipid parameters like total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and increase in high density lipoprotein (HDL) in hyperlipidemic rats as compared to hyperlipidemic control statistically. Conclusions: Our results demonstrated that hydro alcoholic extract of Saussurea lappa seed possessed significant antihyperlipidemic activity and hence it could be a potential herbal medicine as adjuvant with existing therapy for the treatment of hyperlipidemia.