Electrodrugs: an electrochemical prodrug activation strategy
2018
The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(IV) prodrugs into their active Pt(II) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.
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