Direct noninvasive observation of near infrared photobleaching of autofluorescence in human volar side fingertips in vivo
2010
Human transdermal in vivo spectroscopic applications for tissue analysis involving near infrared (NIR) light often must
contend with broadband NIR fluorescence that, depending on what kind of spectroscopy is being employed, can degrade
signal to noise ratios and dynamic range. Such NIR fluorescence, i.e. "autofluorescence" is well known to originate in
blood tissues and various other endogenous materials associated with the static tissues. Results of recent experiments on
human volar side fingertips in vivo are beginning to provide a relative ordering of the contributions from various
sources. Preliminary results involving the variation in the bleaching effect across different individuals suggest that for
830 nm excitation well over half of the total fluorescence comes from the static tissues and remainder originates with the
blood tissues, i.e. the plasma and the hematocrit. Of the NIR fluorescence associated with the static tissue, over half
originates with products of well-known post-enzymatic glycation reactions, i.e. Maillard chemistry, in the skin involving
glucose and other carbohydrates and skin proteins like collagen and cytosol proteins.
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