The role of differential expressed long non-coding RNA in breast cancer

Long non-coding RNA (lncRNA) have deeply effectiveness in different types of tumors, and are participated in tumor progression. Aberrant expressions of lncRNA indicate malignant transformation of tumor, and regulate gene expression respectively through epigenetic, transcriptional and post-transcriptional processes. In details, lncRNA are upregulated or downregulated in breast cancer, which are involved in cell proliferation, apoptosis, cell migration and invasion, cancer cell stemness, chemoresistance as well as prognosis. Therefore, some lncRNA can be served as a potential biomarks for diagnosis and prognosis, and are expected to become novel therapeutic targets. This review summarizes the function and molecular mechanism of lncRNA that are particularly involved in breast cancer progression. Key words: Long non-coding RNA; Breast cancer; Metastasis; Chemo-resistance; Prognosis