Effect of Katakakhadiradi kashayam on liver metabolism in streptozotocin and nicotinamide induced diabetic rats

Plants have the ability to impart therapeutic action on chronic diseases such as diabetes and its comorbidities. The current study was done to find the effectiveness of Katakakhadiradi kashayam on liver metabolism in streptozotocin and nicotinamide administered diabetic rats. Diabetic rats were treated with katakakhadiradi kashayam for 28 days and compared with glibenclamide. The antidiabetic action of Katakakhadiradi kashayam was measured by the serum levels of urea, bilirubin, SGOT and SGPT activity. In the current study, the level of urea, SGPT and SGOT activity was significantly higher and reduced total bilirubin observed in diabetic rats. The protection given by Katakakhadiradi kashayam against diabetic complication was confirmed by a histology study. Most of the plants present in Kadakakhadiradi kashayam are effective in regulating the enzymes in diabetes mellitus. The obtained data imply the antidiabetic effects of katakakhadiradi kashayam, which is practically a safe herbal formulation and can be used as a good alternative for managing DM.