Two-dimensional nanoscale nuclear magnetic resonance spectroscopy enhanced by artificial intelligence

Two-dimensional Nuclear Magnetic Resonance (NMR) is essential to molecule structure determination. Nitrogen vacancy (NV) center in diamond has been proposed and developed as an outstanding quantum sensor to realize NMR in nanoscale. However, it is still lack of two-dimensional nanoscale NMR spectroscopy which is crucial in structure analysis. In our work, combined two-dimensional quantum controls with an artificial intelligence algorithm, the two-dimensional nanoscale NMR spectroscopy is realized on a pair of coupled 13C nuclear spins by NV sensor. Meanwhile, the data consuming time is speeded up by one order with artificial intelligence and compressed sensing protocol, which make the nanoscale NMR more practical. The two-dimensional nanoscale NMR will be the cornerstone to realize nanoscale or even single molecule structure analysis.