Hypocholesterolemic and antihypercholesterolemic activity of extracts of Trichila connaroids on rats

Hypocholesterolemic activity was studied on normal rats for hexane, chloroform and methanol extracts of Trichilia connaroides (W. & A.) Bentilezen. The parameters studied include free cholesterol, triglycerides and high density lipoprotein levels in blood. Only hexane and methanol extracts produced a rise in high density lipoprotein level (p<0.05 at 90 mg/kg) and did not show any fall in cholesterol and triglyceride levels when compared to control group. On Triton-induced hypercholesterolemla, only cholesterol and triglyceride levels were studied for all the three extracts. Chloroform and methanol extracts produced a significant fall in cholesterol level (p<0.05) within 24 h of induction when compared to control group.