Defined Solution Corrects Phenotypic Response and Improves Detection Accuracy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to the 28 Comprehensive In Vitro Proarrhythmia Assay Standards

Haoyu Zeng,Jixin Wang,Holly Clouse,Armando Lagrutta

Defined Solution Corrects Phenotypic Response and Improves Detection Accuracy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to the 28 Comprehensive In Vitro Proarrhythmia Assay Standards

2020

Haoyu Zeng
Jixin Wang
Holly Clouse
Armando Lagrutta

We reported that blockade of Ca2+ channel increased beating rate on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) when in hiPSC-CM culture media, but decreased beating rate...

Keywords:

Blockade
Induced pluripotent stem cell
Proarrhythmia
In vitro
phenotypic response
Cell biology
beating rate
Chemistry

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