Roles of Ezrin in different signal transduction pathways

Ezrin belongs to the Ezrin-Radixin-Moesin (ERM) family, which serve as membrane-cytoskeletal linkage and distributes mainly in the cell cortex. As a linker between membrane proteins and F-actin, Ezrin plays an important part in the regulation of cell morphology, growth, survival, adhesion, proliferation and migration and other biological functions. Its mechanism is complex, involving Rho, PKA, PKC, MAPK, apoptosis and other signal transduction pathways. Therefore, the study of signal transduction related to Ezrin is significant for the understanding of disease progression and Ezrin is probable to be a new treatment target.