ORIGINAL RESEARCH Analysis of 11 C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

RESULTS: MET T/N ratios of DA, OD, and OA were 2.11 0.87, 3.75 1.43, and 2.76 1.27, respectively. The MET T/N ratio of OD was significantly higher than that of DA (P .005). In comparison of MET T/N ratios with the Mib-1 LI, a significant correlation was shown in DA (r 0.63; P .005) but not in OD and OA. CONCLUSION: MET uptake in DAs may be closely associated with tumor viability, which depends on increased amino acid transport by an activated carrier-mediated system. DAs with lower MET uptake were considered more quiescent lesions, whereas DA with higher MET uptake may act more aggressively.