A motif in the V3 domain of the kinase PKC-[theta] determines its localization in the immunological synapse and functions in T cells via association with CD28

The kinase PKC-θ translocates to the center of the immune synapse, but the molecular basis of this interaction is unclear. Altman and colleagues identify a conserved proline-rich motif in the V3 domain of PKC-θ required for its association with CD28 and localization to the immunological synapse.