AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

Zhou et al. show that in the context of AML1-ETO-driven leukaemia, AES and DDX21 induce small nucleolar RNA (snoRNA)–ribonucleoprotein (RNP) formation and this is important for self-renewal of leukaemic cells.