Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)

Jun Li,Stephanie Y. Chen,James J. Li,Haixia Wang,Andres S. Hernandez,Shiwei Tao,Christa Musial,Fucheng Qu,Stephen G. Swartz,Sam T. Chao,Neil Flynn,Brian J. Murphy,Dorothy Slusarchyk,Ramakrishna Seethala,Mujing Yan,Paul G. Sleph,Gary J. Grover,Mark A. Smith,Blake C. Beehler,Leah Giupponi,Kenneth E.J. Dickinson,Hongjian Zhang,William G. Humphreys,Bharat P. Patel,Mark D. Schwinden,Terry R. Stouch,Peter T. W. Cheng,Scott A. Biller,William R. Ewing,David A. Gordon,Jeffrey A. Robl,Joseph A. Tino

Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)

2007

A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.

Keywords:

Biochemistry
Ether
Chemical synthesis
Carbamic acid
Peptidomimetic
Growth hormone secretagogue
In vivo
Tetrazole
Carboxamide
Organic chemistry
Stereochemistry
Chemistry
Secretagogue

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