Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors

Gabriel Gustafsson,Fredrik Eriksson,Christer Möller,Tomás Lopes da Fonseca,Tiago F. Outeiro,Lars Lannfelt,Joakim Bergström,Martin Ingelsson

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors

2017

Gabriel Gustafsson
Fredrik Eriksson
Christer Möller
Tomás Lopes da Fonseca
Tiago F. Outeiro
Lars Lannfelt
Joakim Bergström
Martin Ingelsson

Immunotherapy targeting aggregated alpha-synuclein has emerged as a potential treatment strategy against Parkinson's disease and other alpha-synucleinopathies. We have developed alpha-synuclein oli ...

Keywords:

Antibody
Synuclein
Biochemistry
Immunotherapy
Extracellular
Molecular biology
Monoclonal antibody
Biology
Cell and molecular biology
Bioinformatics
Oligomer
Receptor
α synuclein
Parkinson's disease
Cell biology
Neuroscience

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