Synthesis and Cytotoxicity of Pinostrobin Hydrazone Derivatives

The corresponding hydrazones and thiosemicarbazones were synthesized via the reaction of pinostrobin hydrazone with carbonyl compounds (aromatic aldehydes, acetone) or alkyl(aryl)isothiocyanates, respectively. The new pinostrobin derivatives showed significant cytotoxicity (MTT-assay) against MT-4, CEM-13, and U-937 human tumor cell models.