Novel Functional Hollow and Multihollow Organic Microspheres: Enhanced Efficiency in a Complex, Heterogeneous, Asymmetric, Three-Component/Triple Organocascade Reaction

The pioneered construction of monodisperse hollow and multi-hollow Jorgensen-Hayashi-functionalized microspheres with a well-defined spherical morphology, high surface area and large pore volume were developed by the first dispersion copolymerization of Jorgensen-Hayashi organocatalyst with acrylamide and styrene monomers cross-linked by p-divinylbenzene and ethylene glycol dimethacrylate respectively on the surface of poly(styrene/acrylic acid) (PS) microsphere to form the core-shelled structures, followed by the removal of PS core by etching in organic solvents. The as-prepared hollow and multi-hollow microspheres paved an exquisite strategy to achieve better mass transfer in complex heterogeneous asymmetric three-component/triple cascade reaction in good yields (31-61%) and excellent stereoselectivities (80:20-93:7 dr, >99 %ee).