Nano-ZnO Impregnated on Starch—A Highly Efficient HeterogeneousBio-Based Catalyst for One-Pot Synthesis of Pyranopyrimidinone and Xanthene Derivativesas Potential Antibacterial Agents
2020
A new method has been proposed for the synthesis of pyranopyrimidinone and
xanthene derivatives using zinc oxide–starch nanocomposite as catalyst under
microwave irradiation. The ZnO–starch nanocomposite was characterized by X-ray
diffraction and scanning electron microscopy data, and the size of the
ZnO-starch nanocomposite particles was estimated at 70–90 nm. The catalyst was
used in the three-component condensation of aromatic aldehydes with barbituric
acid and malononitrile and the 1:2 condensation of aromatic aldehydes with
naphthalen-2-ol to obtain pyranopyrimidinone and xanthene derivatives,
respectively. The catalyst can be reused several times without loss of catalytic
activity. The proposed procedure utilizes affordable and inexpensive materials,
provides excellent yields in short reaction time, and is eco-friendly, which
makes it more economic than conventional methods. The antibacterial activity of
the synthesized compounds was evaluated against M.
luteus and P.
aeruginosa.
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