Evaluation of Anti-inflammatory and Antioxidant Effects of Sumatriptan on Carbon Tetrachloride-induced Hepatotoxicity in Rats
2021
The liver detoxifies and metabolizes many drugs and xenobiotics which may cause
hepatotoxicity due to some toxic agents. Carbon tetrachloride (CCl4)
is metabolized in cytochrome P450 and its reactive radical metabolites cause
lipid peroxidation, cellular injury, and apoptosis. Sumatriptan (SUM),
5-HT1B/1D receptor agonist, had anti-inflammatory and anti-oxidant
effects. In this research the effect of SUM pre-treatment against
CCl4-induced hepatotoxicity was examined. Adult rats received SUM
(0.1, 0.3 and 1 mg/kg; i.p.) for 3 consecutive days before
CCl4 (2 ml/kg; i.p. on the 3rd day).
The aminotransferases serum levels, tissue levels of anti-oxidant and
pro-inflammatory markers and histopathological examination were evaluated. SUM
(0.3 mg/kg) prevented significantly the elevation of
aminotransferases versus the control group (CCl4 group)
(P<0.0001) and also, reversed meaningfully the changes of the MPO, MDA,
SOD and CAT, IL-1β and TNF-α levels. Additionally,
CCl4-intoxication resulted to the disruption of lobular and
cellular structures and inflammation in histopathological evaluation which is
prevented by SUM (0.3 mg/kg). These data revealed that SUM
(0.3 mg/kg), but no at doses 0.1 and 1 mg/kg,
decreases the hepatotoxicity of induced by CCl4 in rats.
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