Iatrogenic immunosuppression can lead to prolonged viral shedding and absent immune response to COVID-19

In the era of the COVID-19 pandemic, paediatricians need to remember that immunocompromised children might experience prolonged viral shedding and impaired immunological response to SARS-CoV-2 We report a girl diagnosed with an unresectable angiosarcoma of the liver who underwent liver transplantation in June 2019 The basic immunosuppression protocol consisted of tacrolimus and prednisolone Additionally, she was on adjuvant treatment with trametinib, a mitogen-activated protein kinase (MEK) inhibitor