Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

Abstract A series of pyrrolo[1,2-a]pyrazinone compounds ( 5a – 9f ) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTT method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.