RNase III nucleases from diverse kingdoms serve as antiviral effectors

Lauren C. Aguado,Sonja Schmid,Jared May,Leah R. Sabin,Maryline Panis,Daniel Blanco-Melo,Jaehee V. Shim,David H. Sachs,Sara Cherry,Anne E. Simon,Jean-Pierre Levraud,Benjamin R. tenOever

RNase III nucleases from diverse kingdoms serve as antiviral effectors

2017

Lauren C. Aguado
Sonja Schmid
Jared May
Leah R. Sabin
Maryline Panis
Daniel Blanco-Melo
Jaehee V. Shim
David H. Sachs
Sara Cherry
Anne E. Simon
Jean-Pierre Levraud
Benjamin R. tenOever

RNase III from all three domains of life elicits RNA-targeting antiviral activity that is independent of, and possibly predates, other known eukaryotic antiviral systems.

Keywords:

Three-domain system
Effector
Genetics
Kingdom
Biology
Ribonuclease III
DNA
RNA
Drosha
RNA-dependent RNA polymerase
Viral replication
Polymerase
RNA interference

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