α-Lithiobenzyloxy as a Directed Metalation Group in ortho-Lithiation Reactions

Carlos Sedano,Rocío Velasco,Claudia Feberero,Samuel Suárez-Pantiga,Roberto Sanz

α-Lithiobenzyloxy as a Directed Metalation Group in ortho-Lithiation Reactions

2020

Carlos Sedano
Rocío Velasco
Claudia Feberero
Samuel Suárez-Pantiga
Roberto Sanz

The α-lithiobenzyloxy group, easily generated from aryl benzyl ethers by selective α-lithiation with t-BuLi at low temperature, behaves as a directed metalation group (DMG) providing a direct acces...

Keywords:

Chemistry
Aryl
Medicinal chemistry
Metalation

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